Absolutely! Just pick Base64 from either dropdown. Keep in mind it treats your input as regular text when converting.
Both work fine for input - type however you want. The results will always come out in uppercase though.
You can go up to 10,000 characters. Really big numbers might take a second or two to crunch, but they'll work.
Usually means you've got a character that doesn't belong in that base. Double-check what you typed against the valid characters listed below.
Right now it's whole numbers only. Decimal point support is on the todo list for later updates.